Post by Bob Shephard from Alabama NewsCenter
In his nearly 30 years studying vaccines, Dr. Paul Goepfert, director of the Alabama Vaccine Research Clinic at UAB, has never before seen a vaccine as effective as the three COVID-19 vaccines – from Pfizer, Moderna and Johnson & Johnson – available in the United States.
“A 90% decrease in risk of infections and 94% effectiveness against hospitalization for the Pfizer and Moderna vaccines is fantastic,” he said.
But what makes vaccine experts such as Goepfert confident that COVID-19 vaccines are safe in the long term? Most people have seen billboards and TV commercials from law firms seeking people harmed by diet drugs or acid-reflux medicines for class-action lawsuits. What makes Goepfert think that scientists would not discover previously unsuspected problems caused by COVID-19 vaccines in the years ahead?
There are several reasons. Vaccines, given in one- or two-shot doses, are very different from medicines that people take every day, potentially for years. And decades of vaccine history – plus data from more than 1 billion people who have received COVID-19 vaccines since December 2020 – provide powerful proof there is little chance that any new dangers will emerge from COVID-19 vaccines.
The majority of Americans who have not been vaccinated – or who say they are hesitant about vaccinating their children – report that safety is their main concern. Nearly a quarter of respondents in Gallup surveys in March and April said they wanted to confirm the vaccine was safe before getting the shot. And 26% of respondents in an April Kaiser Family Foundation survey of parents with children ages 12-15 said they wanted to “wait a while to see how the vaccine is working” before deciding to get their children vaccinated.
But Goepfert said scientists already know enough to be confident the COVID-19 vaccines are safe. Here is why, starting with the way vaccines work and continuing through strong evidence from vaccine history and stronger evidence from responses of people who have received COVID-19 vaccines worldwide the past six months.
Vaccines are eliminated quickly
Unlike many medications that are taken daily, vaccines are generally one-and-done. Medicines taken every day can cause side effects that reveal themselves over time, including long-term problems as levels of the drugs build up in the body over months and years.
“Vaccines are just designed to deliver a payload and then are quickly eliminated by the body,” Goepfert said. “This is particularly true of the mRNA vaccines; mRNA degrades incredibly rapidly. You wouldn’t expect any of these vaccines to have any long-term side effects. And in fact, this has never occurred with any vaccine.”
Vaccine side effects show up within weeks, if at all
That is not to say that there have never been safety issues with vaccines. But in each instance, these have appeared soon after widespread use of a vaccine began.
“The side effects that we see occur early on, and that’s it,” Goepfert said. “In virtually all cases, vaccine side effects are seen within the first two months after rollout.”
The only vaccine program that might compare with the scale and speed of the COVID-19 rollout is the original oral polio vaccine in the 1950s. When this vaccine was introduced in the United States in 1955, it used a weakened form of the polio virus that in very rare cases – about one in 2.4 million recipients – became activated and caused paralysis. (Compare this with the 60,000 children infected with polio in the United States in 1952, and the more than 3,000 children who died from the disease in the United States that year.) Cases of vaccine-induced paralysis occurred between one and four weeks after vaccination. None of the COVID-19 vaccines uses a weakened form of the SARS-CoV-2 virus – all of the coronavirus vaccines train the body to recognize a piece of the virus known as the spike protein and generate antibodies that can attack the virus in case of an infection.
In 1976, a vaccine against swine flu that was widely distributed in the United States was identified in rare cases (approximately one in 100,000) as a cause of Guillain-Barré Syndrome, in which the immune system attacks the nerves. Almost all of these cases occurred in the eight weeks after a person received the vaccine. But the flu itself can cause Guillain-Barré Syndrome; in fact, the syndrome occurs 17 times more frequently after natural flu infection than after vaccination.
COVID-19 vaccine experience over the past six months
“By the time the Pfizer and Moderna COVID vaccines were approved for emergency use in the United States in December 2020, we already knew the short-term side effects very well from the efficacy studies,” Goepfert said. “Pfizer and Moderna – and later Johnson & Johnson and then Novavax, which reported on its phase III trial results in June – all have enrolled 30,000-plus individuals, half of whom got the vaccine and half of whom got a placebo initially, after which all the placebo group got the vaccine.”
The side effects seen in these studies, and again in the nationwide rollouts that began in December 2020, were tolerability issues, Goepfert said, mainly arm pain, fatigue and headache. These are very transient and occur a day or two after the vaccine. They then resolve quickly.
As of July 15, more than 3.54 billion COVID-19 vaccine doses had been administered worldwide, according to the New York Times vaccinations tracker.
Goepfert said that between December and June, doctors began to see more-rare side effects that do not show up until millions of people have gotten a vaccine.
About one in 100,000 people receiving the AstraZeneca COVID-19 vaccine have experienced a clotting disorder known as thrombotic thrombocytopenia, including 79 cases among more than 20 million people receiving this vaccine in the United Kingdom, which led to 19 deaths. A smaller number of cases have occurred with Johnson & Johnson’s vaccine as well, Goepfert said.
“The causes are still being worked out, but when this happens, it occurs from six days to two weeks after vaccination,” he said. “More recently, an even more-rare side effect – myocarditis, or inflammation of the heart muscle – has been reported in people receiving Pfizer and Moderna COVID-19 vaccines. That is about one in a million, or possibly higher rates in some populations; but again, all of these occur no more than a month after the vaccination.”
Weighing the odds
Any risk is frightening, especially for a parent. But the rare side effects identified with COVID vaccines have to be weighed against the known, higher risks from contracting COVID, Goepfert said. It is not clear how COVID variants such as the highly infectious Delta mutation may affect patients. Early indications are that Delta infections bring more severe side effects than other forms of COVID, but that vaccines are still protective against Delta.
It is COVID infection, and the growing evidence of persistent symptoms from what has become known as “long COVID,” that are the most troubling unknown out there, Goepfert said.
“The long-term side effects of COVID infection are a major concern,” he said. “Up to 10 percent of people who have COVID experience side effects such as difficulty thinking, pain, tiredness, loss of taste and depression. We don’t know why that is, how long these symptoms will last or if there are effective ways to treat them. That is the most troubling unknown for me.”
Even as cases, hospitalizations and deaths have declined significantly in Alabama since January, the number of new cases has risen in the past month. As of July 14, the state was averaging 529 new cases per day.
“Many people worry that these vaccines were ‘rushed’ into use and still do not have full FDA approval — they are currently being distributed under Emergency Use Authorizations,” Goepfert said. “But because we have had so many people vaccinated, we actually have far more safety data than we have had for any other vaccine, and these COVID vaccines have an incredible safety track record. There should be confidence in that.”
This story originally appeared on the UAB News website.
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